It has been a tricky few days for the Reds after they lost Virgil van Dijk to long-term injury in the Merseyside derby on Saturday, a contest which ended 2-2 and left them three points behind their local rivals.
Ajax have had a good, but not perfect, start to their Eredivisie campaign, winning four and losing one of their first five matches and will be looking to pounce on a Liverpool side not at full strength.
When is Ajax vs Liverpool?
The match kicks off at 8pm on Wednesday 21 October.
What TV channel is Ajax vs Liverpool on and is there a live stream?
BT Sport 2 will be showing the game live with coverage starting at 7.15pm.
Subscribers can stream the action on BT Sport Player or on the BT Sport app.
Virgil van Dijk is set for months out with an ACL tear and Joel Matip is also ruled out of this game after a muscle strain at the weekend.
This leaves Joe Gomez as the only natural centre-back for Liverpool and he is set to be partnered by Fabinho at the back.
Thiago Alcantara will sit out the game with a knock and Alisson Becker remains sidelined, as does Alex Oxlade-Chamberlain.
Ajax vs Liverpool odds
Odds courtesy of Betfair
Ajax vs Liverpool head-to-head
07 Dec 1966: Ajax 5-1 Liverpool – European Cup
14 Dec 1966: Liverpool 2-2 Ajax – European Cup