The Gunners are on a woeful run of form, with defeat to Burnley on Sunday night leaving them 15th in the table with three straight losses.
The Saints are in completely contrasting form, fourth in the table and just two points off Spurs at the top of the division.
Only two clubs have scored more than Southampton in the Premier League this season while only two have scored less than Arsenal.
What time is Arsenal vs Southampton?
The match is at 6pm on Wednesday 16 December at the Emirates.
What TV channel is Arsenal vs Southampton on and is there a live stream?
Amazon Prime will be showing the game live , with subscribers able to stream the action.
Arsenal vs Southampton team news
Arsenal are missing Granit Xhaka and Hector Bellerin through suspension, while Thomas Partey and Gabriel Martinelli remain out injured.
Arteta is hoping to have David Luiz, Reiss Nelson and Sead Kolasinac available after knocks.
Southampon’s excellent recent form has been helped by a clean bill of health and they still have the full squad available.
Arsenal vs Southampton odds
Odds courtesy of Betfair
Arsenal vs Southampton head-to-head in last five meetings
25 Jun 2020: Southampton 0-2 Arsenal – Premier League
23 Nov 2019: Arsenal 2-2 Southampton – Premier League
24 Feb 2019: Arsenal 2-0 Southampton – Premier League
16 Dec 2018: Southampton 3-2 Arsenal – Premier League
08 Apr 2018: Arsenal 3-2 Southampton – Premier League
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