The 32-year-old has already been axed from Arsenal’s Europa League squad and he was not named in their 25-man Premier League list which was submitted on Tuesday.
The decision means that Ozil will be unable to play for Arsenal until February and the midfielder is likely to have played his final game for the Gunners.
And Wenger, who brought Ozil to Arsenal for £42.4 million in 2013, has advised the midfielder to focus on staying in shape in preparation for his next transfer.
Asked how Ozil should respond if he is left out of Arsenal’s Premier League squad, Wenger told Sky Sports: ‘You practice every day and you make sure that your level doesn’t drop and that you can go somewhere else after and play somewhere else.’
Asked if he has spoken to Ozil, Wenger said: ‘No, I haven’t spoken to him since I left.
‘Because I decided to take a distance and not interfere with anything.
‘I explained in my book, when you’ve been [at a club] for such a long time it’s important you cut at some stage your relations and let them get on with it.’
Wenger has also suggested that Arteta’s decision to omit Ozil from Arsenal’s squad is not entirely based on sporting reasons.
‘I don’t know what’s happening on a daily basis. I just say one thing, the creative players are the players who are perfectionists and they are a bit more sensitive sometimes and they need to be encouraged,’ said Wenger.
‘Mesut Ozil is an exceptional football player. What’s happening at the moment between him and the club looks to be more confrontational, it’s not [only] based on sport, I’m convinced.
‘This guy has won things. He’s a world champion, he’s an exceptional football player.
‘Why is he not at the moment playing? I don’t know. When you’re a football player you have to respect the decision of your manager and fight to get your confidence and get back into the team again.
‘He can fight, contrary to what people think, he can fight. And he’s an exceptional football player, he has enough quality to get back into the team. So it’s down to him to get his confidence back.’