As a result, the Villains will be fielding a team almost entirely of Under-23 players, with manager Dean Smith also not involved and Mark Delaney, the Under-23 coach, taking charge.
The entire first team squad and staff have gone into isolation, but enough negatives have come back from the Under-23s and youth teams for the game to go ahead.
Liverpool were favourites to win the game anyway, but have seen their odds slashed as they will be taking on an extremely inexperienced Villa side.
When is Aston Villa vs Liverpool?
The match kicks-off at 7.45pm on Friday 8 January at Villa Park.
What TV channel is Aston Villa vs Liverpool on and is there a live stream?
BT Sport 1 will be showing the game live with coverage from 7pm.
Subscribers can stream the action on BT Sport Player or on the BT Sport app.
As mentioned, no first team players will be involved for Aston Villa, meaning a team of largely unknowns will be taking to the field.
Jurgen Klopp may choose to rest more players than he would have done as a result, although he is definitely without Virgil van Dijk, Joe Gomez, Joel Matip, Naby Keita, Diogo Jota and Kostas Tsimikas, so his options are slightly limited.
Aston Villa vs Liverpool odds
14/1 Aston Villa
Odds courtesy of Betfair
Aston Villa vs Liverpool head-to-head in last five meetings
04 Oct 2020: Aston Villa 7-2 Liverpool – Premier League
05 Jul 2020: Liverpool 2-0 Aston Villa – Premier League
17 Dec 2019: Aston Villa 5-0 Liverpool – League Cup
02 Nov 2019: Aston Villa 1-2 Liverpool – Premier League
14 Feb 2016: Aston Villa 0-6 Liverpool – Premier League