The Blues are proving to be a thrilling watch in the Premier League, scoring 13 and conceding nine in their opening five games, but they have only picked up eight points in that time after their 3-3 draw with Southampton on Saturday.
Sevilla started the campaign with two wins but have since drawn and lost their last two matches to leave them off the pace in La Liga.
With Rennes and Krasnodar the other two teams in Group E, the English and Spanish teams are expected to battle it out for the top two spots.
When is Chelsea vs Sevilla?
The match kicks-off at 8pm on Tuesday 20 October at Stamford Bridge.
BT Sport 3 will be showing the game live with coverage starting at 7.15pm.
Subscribers can stream the action on BT Sport Player or on the BT Sport app.
Chelsea vs Sevilla team news
Chelsea are hoping to have goalkeeper Edouard Mendy available as he pushes to recover from a thigh injury in time.
He sat out the 3-3 draw with Southampton on Saturday, with Kepa Arrizabalaga struggling again in goal, but has trained since and could start.
Marcos Alonso is suspended, but was unlikely to start anyway, with Ben Chilwell at left-back. Billy Gilmour remains out.
Chelsea vs Sevilla odds
Odds courtesy of Betfair