Leicester City, who are in the competition for the first time, will take on Braga, AEK and FC Zorya Luhansk.
Celtic have been handed a tough group as they will play AC Milan, Lille and Sparta Prague.
Meanwhile, Rangers will face Benfica, Standard Liege and Lech Poznan.
The first matches of the group stage will take place on October 22.
The final is due to be held at the Stadion Energa Gdansk in Poland on May 26, 2021.
EUROPA LEAGUE DRAW
Roma, Young Boys, CFR Cluj, CSKA Sofia
Arsenal, Rapid Vienna, Molde, Dundalk
Bayer Leverkusen, Slavia Prague, Hapoel Beer-Sheva, Nice
Benfica, Standard Liege, Rangers, Lech Poznan
PSV, PAOK, Granada, AC Omonia
Napoli, Real Sociedad, AZ Alkmaar, HNK Rijeka
Braga, Leicester City, AEK, FC Zorya Luhansk
Celtic, Sparta Prague, AC Milan, Lille
Villarreal, Qarabag, Maccabi Tel Aviv, Sivasspor
Tottenham, Ludogorets, LASK, Royal Antwerp
CSKA Moscow, Dinamo Zagreb, Feyenoord, Wolfsberger AC
Gent, Red Star, Hoffenheim, Liberec