The 27-year-old was a notable absentee from Ole Gunnar Solskjaer’s squad as the Norwegian named a second string XI to face the Seagulls.
Maguire has featured in every single United game since the FA Cup fourth round clash against Derby County in February and he played 55 times for the club in his debut season at Old Trafford.
United take on Brighton for the second time in four days but Maguire’s absence was a worry for supporters, who already have one eye on Jose Mourinho’s return to the Theatre of Dreams on Sunday.
However, Solskjaer has allayed fears that Maguire is set for a stint on the sidelines.
‘He’s got a little knock but should be okay,’ Solskjaer told MUTV.
Eric Bailly partners Victor Lindelof in Maguire’s absence at the Amex Stadium.
Solskjaer had hinted before Saturday’s 3-2 win that Bailly was in line to play alongside Maguire against the Seagulls but the Norwegian kept Lindelof and Maguire together once again.
United have conceded five goals in their opening two Premier League matches and Brighton hit the woodwork five times in Saturday’s win.
That’s led to speculation that the club will make an emergency signing at the back but Solskjaer insists he’s happy with his option.