The Gunners are without a win in five Premier League matches and lost their fourth consecutive game at home in the league on Sunday as they were beaten by Burnley.
Granit Xhaka is suspended for the match against Southampton following his red card in the defeat to Burnley.
But Wright believes that Lacazette and Willian should also lose their place in their team following their poor form in recent weeks.
‘He [Xhaka] got sent off doing what he does a lot, when a player is going past him he drags them down, he’s never in the right position, he’s always having to drag people down and make fouls, and he’s done it again and it cost us,’ Wright told Premier League Productions.
‘The manager has stuck with him for a while. He has shown a lot of faith in him.
‘I think he has done the same with Willian. He has done the same with Lacazette.
‘There are players now that should be getting a blast at it now.
‘Throw in Eddie Nketiah, Emile Smith-Rowe coming back on-loan and doing well at Huddersfield last season. Joe Willock, Ainsley Maitland-Niles.
‘You need to do something different because if it carries on like this and he continues to have faith in these players, and they are not delivering, then I don’t know what’s going to happen next.
‘I feel like at this particular moment, he has had a lot of faith in them and they have kind of let him down up to this point.
‘I think Arsenal are at a real crisis point in terms of confidence. It’s going to be even lower now and it’s going to take something to build them up.
‘This is why it needs some freshness. Just blood some fresh impetus.’