De Bruyne has sat out the last two games, while Laporte has made just one appearance so far this season as Man City suffer something of a disjointed start to their campaign.
Guardiola’s side have already dropped points in two of their four Premier League contests, losing to Leicester City and drawing with Leeds, but they have responded well, beating Arsenal at the weekend and coming from behind to down Porto in the Champions League on Wednesday night.
It was after the win in Europe that Guardiola gave an update on De Bruyne and Laporte, while also ruling Fernandinho out for a number of weeks with an injury after the Brazilian came on and was subbed off late in the game.
‘I think Kevin and Laporte start training tomorrow [Thursday] but I don’t know how they will be tomorrow and the next days so we will see,’ said the Spanish boss.
‘Unfortunately people came back and now we have lost another but it is really important to come back.
‘It’s bad news [on Fernandinho]. It’s in his leg I think he will be out for four to six weeks. it is a big blow for us because we need people there.’
Gabriel Jesus has also sat out recent matches and while he is recovering, Guardiola has been vague over his fitness timeframe, only saying he is expected back ‘in the next weeks’.