Ole Gunnar Solskjaer’s side are still top of their group after fine wins over Paris Saint-Germain and RB Leipzig, which made the result in Turkey all the more puzzling.
What time is Man Utd vs Istanbul Basaksehir?
The match kicks-off at 8pm on Tuesday 24 November at Old Trafford.
BT Sport 2 will be showing the game live with coverage starting at 7pm.
Subscribers can stream the match on BT Sport Player or on the BT Sport app.
Man Utd vs Istanbul Basaksehir team news
Manchester United are definitely without Luke Shaw, Phil Jones and Jesse Lingard, while Eric Bailly is a doubt.
Paul Pogba is expected to be available after missing the weekend win over West Brom with a knock, while Mason Greenwood should be back after illness.
Dean Henderson may well be back in goal in the Champions League, while summer signing Alex Telles will continue at left-back.
Man Utd vs Istanbul Basaksehir odds
1/4 Man Utd
Odds courtesy of Betfair