The 27-year-old was expected to be called up to France’s national squad ahead of their Nations League matches against Sweden and Croatia in September.
But the French Football Federation (FFF) has confirmed that Pogba will not be brought into the squad and has been replaced by Rennes midfielder Eduardo Camavinga.
‘I had to make a change at the very last minute since Paul Pogba was included in this list but he tested last night which turned out positive this morning,’ France head coach Didier Deschamps said on Thursday.
Pogba was due to begin pre-season training with United next Wednesday.
But the midfielder will now self-isolate for 14 days and will miss the start of United’s preparations for the new campaign.
A statement from United read: ‘Pogba has been replaced in the squad after testing positive for COVID-19. The midfielder will be unable to add to his 69 caps and 10 goals for his country in the games next month.
‘Everybody at United wishes Paul a speedy recovery ahead of the new season.’
The news will come as a further blow for Ole Gunnar Solskjaer as he is already without Aaron Wan-Bissaka for the start of United’s pre-season camp as the right-back faces a 14-day quarantine following a holiday in Dubai.
The 24-year-old enjoyed his best season in front of goal for United last term, scoring 23 times in 48 appearances.
‘Since the World Cup, three or four times he [Martial] was due to be part of our squad, for various different reasons it didn’t happen,’ said Deschamps.
‘With what he has been doing since last season, now he is back in the squad.’
Tottenham midfielder Tanguy Ndombele has also tested positive for coronavirus and will not be called up for France’s national side.
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