The Brazil international has been restricted to just one appearance for his new club following his transfer deadline day move from Porto.
Telles impressed on his debut against Paris Saint-Germain in the Champions League a fortnight ago but has missed the last four matches after he tested positive for Covid-19.
The 27-year-old has now completed a two-week period of quarantine and has tested negative for the virus.
United face Everton at Goodison Park in Saturday’s early kick-off and Telles is in contention to make his return at left-back, potentially in place of Luke Shaw, after taking part in first team training on Friday.
Should Brighton win at Burnley on Friday evening, United could start tomorrow’s fixture in 16th place and Ole Gunnar Solskjaer can hardly afford another setback with the pressure mounting on him
Addressing speculation surrounding his future following the midweek defeat in Istanbul, Solskjaer said: ‘I decline to comment on such a thing.
Metro.co.uk understands that Solskjaer is in no immediate danger of the sack, but United’s hand could be forced if results do not improve, while Manchester City’s interest in Mauricio Pochettino, out of work since leaving Spurs 12 months ago, could represent a factor in any decision the club makes on their current manager.