Marcus Rashford, Bruno Fernandes and Scott McTominay started United’s previous matches with PSG and Chelsea but all three drop to the substitutes bench at Old Trafford after a gruelling period for the trio.
Paul Pogba, Mason Greenwood, Anthony Martial and Nemanja Matic all come into the Red Devils’ team for this evening’s Group H clash.
Summer signing Van de Beek arrived with a sizeable reputation from Ajax back in August but has had to be patient for first-team opportunities under Solskjaer thus far and is yet to start in the Premier League for the Red Devils.
However, the Netherlands midfielder has a huge chance to impress alongside Pogba in the middle of the park this evening and Solskjaer is confident he’s picked a side more than capable of victory.
On Van de Beek and Pogba starting, Solskjaer told BT Sport: ‘They’ve been waiting in the wings and we picked a team that we think can cause Leipzig problems tonight.
Asked why Fernandes and Rashford only start on the bench, he explained: ‘Bruno and Marcus have played the last five – or they’ve played three for us and played two internationals – Scott has played the last three plus three internationals.
‘So five games in 14 days, six games in 17 for Scotty. You’ve got to look after the players and medically that’s what we deemed right today.’
The United head coach is wary of a strong Leipzig side that remain unbeaten in all competitions this season under Julian Nagelsmann, widely regarded as one of the top young managers in European football.
‘They’re very high tempo, high energy, tactically very adept and you never know how he’s going to set his team up,’ Solskjaer said.
‘We have to cause them more problems than they cause us.’
‘We picked the team that we think can win the game and cause them problems.
‘I always pick a team that I think can win the game.’