The Gunners make the short trip across London to face Spurs on Sunday sitting 14th in the Premier League and having lost five of their last eight league matches.
Tottenham, meanwhile, have enjoyed an impressive start to the season under Jose Mourinho and are currently top on goal difference.
Merson says Arsenal are struggling because Arteta’s ‘go-to players’ are not turning up and reserved particularly stinging criticism for Aubameyang and Willian.
Aubameyang has been arguably Arsenal’s most important player over the past three seasons but has scored only two goals in this year’s Premier League campaign.
Brazil international Willian, meanwhile, has failed to hit the heights which saw him win multiple Premier League titles at Chelsea following his summer move from Stamford Bridge.
Merson told the Daily Star: ‘Mikel Arteta is struggling because his go-to players haven’t turned up this season and that is a big, big problem.
‘I don’t see how my old club can beat Tottenham this weekend. They are too predictable and getting nothing from their stars.
‘Willian has not got going at all, and is having a real nightmare. And Pierre-Emerick Aubameyang has been atrocious.
‘What does he bring to the party? Absolutely nothing at the moment. You need big performances from your big players when things aren’t going well. Arsenal aren’t getting that. That’s a dangerous thing.
The Gunners legend added: ‘I don’t even think they have a plan to get players like Aubameyang and Willian on the ball. They hardly touch it in some games.
‘If you touch the ball 80 times in a game, you are going to do at least 10 good things.
‘But I watch him in the Premier League and at the moment, Aubameyang is doing absolutely nothing at all.
‘You have got to get them into the game. Get them more involved somehow. Arsenal are a bit too predictable.
‘If Aubameyang plays in the North London Derby, he really needs to show up. And if he doesn’t, Arsenal have to find a solution.’