The Red Devils will face the likes of Neymar, Kylian Mbappe, Angel di Maria and Julian Draxler without captain Harry Maguire and fellow centre-back Eric Bailly also out.
PSG have won their last five games with an aggregate score of 16-1 and will be looking for revenge from their memorable defeat to United in 2019.
Having lost the first leg of their last 16 tie 2-0 at home, the Red Devils famously went to Paris and won 3-1 to progress to the quarter-finals in style.
Bruno Fernandes will captain United for the first time in the absence of Maguire.
When is PSG vs Man Utd?
The game kicks-off at 8pm on Tuesday 20 October at the Parc des Princes.
BT Sport 2 will be showing the game live with coverage starting at 7pm.
Subscribers can stream the action on BT Sport Player or on the BT Sport app.
PSG vs Man Utd team news
Manchester United are struggling with a number of injuries, with Solskjaer saying: ‘We are a little bit depleted but we have more than enough players.’
Their defence looks short of options with Harry Maguire and Eric Bailly out injured, leaving Victor Lindelof in central defence, possibly alongside Axel Tuanzebe.
Edinson Cavani is not ready to make his debut, Mason Greenwood is out, as is Jesse Lingard.
PSG are also missing players, with Marco Verratti, Leandro Paredes, Mauro Icardi, Thilo Kehrer and Juan Bernat all out.
PSG vs Man Utd odds
5/1 Man Utd
Odds courtesy of Betfair
PSG vs Man Utd head-to-head
12 Feb 2019: Man Utd 0-2 PSG – Champions League
06 Mar 2019: PSG 1-3 Man Utd – Champions League