United suffered their first loss in the Champions League group stage this season as they were beaten 2-1 in Turkey.
Ole Gunnar Solskjaer’s side were heavily exposed for both of the goals they conceded in the first half, with Paul Scholars describing the defending as ‘comical’ and ‘laughable’.
But Van Persie also feels Solskjaer’s players went against the philosophy Ferguson used to impose on the United squad during his time at Old Trafford.
‘They missed the urgency to commit,’ Van Persie told BT Sport.
‘In my time at Manchester United, Sir Alex Ferguson said: ‘I don’t mind losing as long as my team is not running less than the opponent and I want to see commitment going forward and as well defensively’.
‘I’m pretty sure Basaksehir ran more than Manchester United. That should never be the case in any game.
‘That has nothing to do with quality or abilities. That’s extra. You need to commit, to be there with 100 per cent focus.’
Demba Ba opened the scoring for the hosts after he left unmarked in his own half and allowed to run clean through on United’s goal.
Speaking about the incident, Van Persie said: ‘I’ve never seen a goal conceded like that first goal, usually you leave two defenders at the back.’
‘Surely you always have someone back on the halfway line, they’re pointing at Matic. You’re always goalside, it’s like Under-10s football,’ said the former United midfielder.
‘You can understand if it’s last minute but it’s the first 10 minutes, it’s embarrassing.
‘They’ve struggled with them attacking wise, they’ve gone with one holding player today. Defensively they’re all over the place.
‘The defenders have to be better, forward play could be better as well. Defensively they’ve got to take responsibility, you have to defend one-on-one sometimes when you’re at Manchester United they seem incapable of doing it.’