The Ghanaian midfielder hobbled off in a 3-0 defeat against Aston Villa and missed Arsenal’s last four matches, but he has been thrust into the starting line-up by Mikel Arteta on Sunday.
He will partner Granit Xhaka in the heart of the Arsenal midfield, with Bukayo Saka, Willian, Alexandre Lacazette and Pierre-Emerick Aubameyang playing in front of them.
Hector Bellerin, Rob Holding, Gabriel Magalhaes and Kieran Tierney will sit in front of goalkeeper Bernd Leno.
For Spurs, Harry Kane and Hugo Lloris – both of whom were doubts – have also made the starting line-up.
Spurs vs Arsenal teams
Spurs: Lloris, Aurier, Alderweireld, Dier, Reguilon, Hojbjerg, Sissoko, Lo Celso, Bergwijn, Son, Kane.
Arsenal: Leno, Bellerin, Holding, Gabriel, Tierney, Partey, Xhaka, Saka, Willian, Lacazette, Aubameyang.
Serge Aurier, Toby Alderweireld, Eric Dier and Sergio Reguilon make up the back-four, with Pierre-Emile Hojbjerg and Moussa Sissoko offering protection in midfield.
Giovanni Lo Celso will be expected to provide some creativity to feed the fearsome attacking trio of Kane, Son Heung-Min and Steven Begwijn.
Gareth Bale is among the substitutes for Jose Mourinho’s side.