Both teams have had mixed starts to their Premier League campaigns, with both picking up four points from their first three games.
What might be considered a reasonably even match in other circumstances, Spurs have such a busy early-season schedule that they are playing again just two days later in the Europa League and the odds reflect the face that Mourinho will likely rest the majority of the first team squad.
Despite a multiple changes coming for Spurs, Mourinho outcast Dele Alli is not expected to be included.
The match kicks-off at 7.45pm on Tuesday 29 September at the Tottenham Hotspur Stadium.
Sky Sports Main Event and Sky Sports Football will be showing the game live with subscribers able to stream the action on Sky Go or the Sky Sports app.
Non-subscribers can stream the match with a Sky Sports Pass on Now TV.
Tottenham are without Gareth Bale and Heung-min Son through injury, but plenty more first team players will also miss out due to their punishing schedule.
Jose Mourinho has already made it clear that he will be focussing on their Europa League qualifier on Thursday night, so will not be able to risk players in this game.
‘I would like to fight for the Carabao but I don’t think I can,’ he said. ‘The group phase of the Europa League gives us a certain amount of money that for a club like us is very important.
‘I think you can imagine that with a game on Thursday that decides a very important thing for us, I think the EFL made a decision for us,” he said.
‘They didn’t even create a problem – they made a decision for us. So that’s the decision.’
Chelsea boss Frank Lampard will also rest players, but will likely field a much stronger team than Mourinho.
Christian Pulisic and Hakim Ziyech remain out through injury.
Tottenham vs Chelsea odds
Odds courtesy of Betfair