The Spaniard was forced off at half-time in last weekend’s win over Southampton with a knee injury, but returned to play the full 90 minutes in the loss to Paris Saint-Germain in midweek.
However, Dean Henderson was awarded his first Premier League start for the Red Devils as he replaced De Gea in the starting XI to play the Hammers.
Speaking to MUTV before kick-off at the London Stadium, Ole Gunnar Solskjaer confirmed that no risks were being taken with De Gea’s injury, while he hopes that the goalkeeper will be fit to play in the crunch clash against Leipzig on Tuesday.
‘The injury against Southampton is something we don’t want to take a risk with,’ the Norwegian boss said.
‘He played against PSG and hopefully he will be ready for Leipzig.’
Solskjaer made a further three changes from the team that lost 3-1 to PSG on Wednesday night.
Paul Pogba, Donny van de Beek and Mason Greenwood were all drafted in, while Fred wasn’t included in the squad and Bruno Fernandes and Marcus Rashford were benched.
A draw away in Germany will be enough to see the Red Devils progress to the round of 16.